| http://purl.uniprot.org/citations/30602418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30602418 | http://www.w3.org/2000/01/rdf-schema#comment | "The Hepatitis C virus (HCV) core protein plays a crucial role in the development of chronic liver diseases such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Its involvement in these diseases is reportedly abolished by a knockout of the proteasome activator PA28γ gene in transgenic mice, suggesting an interaction between the core protein and the PA28γ-proteasome system. This study found a direct interaction between the N-terminal 1-71 fragment of HCV core protein (Core71) and PA28γ in vitro, and that this interaction was found to enhance PA28γ-20S proteasome complex formation. While 20S proteasome activity was increased by PA28γ, it was significantly reduced by Core71 attachment in a dose-dependent manner. These results suggest that the Core-PA28γ interaction has an important role in regulating 20S proteasome activity and furthers our understanding of the pathogenesis of HCV."xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2018.12.167"xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/author | "Matsuura Y."xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/author | "Yoshida T."xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/author | "Ohkubo T."xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/author | "Kawahara K."xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/author | "Shimamoto S."xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/author | "Maruno T."xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/pages | "590-595"xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/title | "N-terminal HCV core protein fragment decreases 20S proteasome activity in the presence of PA28gamma."xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://purl.uniprot.org/core/volume | "509"xsd:string |
| http://purl.uniprot.org/citations/30602418 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30602418 |
| http://purl.uniprot.org/citations/30602418 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30602418 |
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| http://purl.uniprot.org/uniprot/#_K9J957-mappedCitation-30602418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30602418 |
| http://purl.uniprot.org/uniprot/#_P61289-mappedCitation-30602418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30602418 |
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| http://purl.uniprot.org/uniprot/#_Q6MZZ1-mappedCitation-30602418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30602418 |