| http://purl.uniprot.org/citations/30604749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30604749 | http://www.w3.org/2000/01/rdf-schema#comment | "MLL3 and MLL4 are two closely related members of the SET1/MLL family of histone H3K4 methyltransferases and are responsible for monomethylating histone H3K4 on enhancers, which are essential in regulating cell-type-specific gene expression. Mutations of MLL3 or MLL4 have been reported in different types of cancer. Recently, the PHD domains of MLL3/4 have been reported to recruit the MLL3/4 complexes to their target genes by binding to histone H4 during the NT2/D1 stem cell differentiation. Here we show that an extended PHD domain (ePHD6) involving the sixth PHD domain and its preceding zinc finger in MLL3 and MLL4 specifically recognizes an H4H18-containing histone H4 fragment and that modifications of residues surrounding H4H18 modulate H4 binding to MLL3/4. Our in vitro methyltransferase assays and cellular experiments further reveal that the interaction between ePHD6 of MLL3/4 and histone H4 is required for their nucleosomal methylation activity and MLL4-mediated neuronal differentiation of NT2/D1 cells."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-07906-3"xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/author | "Lei M."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/author | "Qin S."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/author | "Min J."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/author | "Dong A."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/author | "Loppnau P."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/author | "Lee M.G."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/author | "Chen T.Y."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/author | "Ho J.C."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/author | "Dhar S.S."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/pages | "36"xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/title | "Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4."xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/30604749 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30604749 |
| http://purl.uniprot.org/citations/30604749 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30604749 |
| http://purl.uniprot.org/uniprot/#_P62805-mappedCitation-30604749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30604749 |
| http://purl.uniprot.org/uniprot/#_Q9UMN6-mappedCitation-30604749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30604749 |
| http://purl.uniprot.org/uniprot/#_Q8NEZ4-mappedCitation-30604749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30604749 |
| http://purl.uniprot.org/uniprot/Q8NEZ4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30604749 |