| http://purl.uniprot.org/citations/30605519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30605519 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies have enabled the identification of important factors regulating cancer progression, such as paired box gene 5 (Pax-5). This transcription factor has consistently been associated to B-cell cancer lesions and more recently solid tumors including breast carcinoma. Although Pax-5 downstream activity is relatively well characterized, aberrant Pax-5 expression in a cancer-specific context is poorly understood. To investigate the regulation of Pax-5 expression, we turned to micro RNAs (miRNAs), small non-coding RNA molecules that regulate key biological processes. Extensive studies show that miRNA deregulation is prevalent in cancer lesions. In this study, we aim to elucidate a causal link between differentially expressed miRNAs in cancer cells and their putative targeting of Pax-5-dependent cancer processes. Bioinformatic prediction tools indicate that miRNAs 484 and 210 are aberrantly expressed in breast cancer and predicted to target Pax-5 messenger RNA (mRNA). Through conditional modulation of these miRNAs in breast cancer cells, we demonstrate that miRNAs 484 and 210 inhibit Pax-5 expression and regulate Pax-5-associated cancer processes. In validation, we show that these effects are probably caused by direct miRNA/mRNA interaction, which are reversible by Pax-5 recombinant expression. Interestingly, miRNAs 484 and 210, which are both overexpressed in clinical tumor samples, are also modulated during epithelial-mesenchymal transitioning and hypoxia that correlate inversely to Pax-5 expression. This is the first study demonstrating the regulation of Pax-5 expression and function by non-coding RNAs. These findings will help us better understand Pax-5 aberrant expression within cancer cells, creating the possibility for more efficient diagnosis and treatments for cancer patients."xsd:string |
| http://purl.uniprot.org/citations/30605519 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgy191"xsd:string |
| http://purl.uniprot.org/citations/30605519 | http://purl.uniprot.org/core/author | "Ouellette R.J."xsd:string |
| http://purl.uniprot.org/citations/30605519 | http://purl.uniprot.org/core/author | "Robichaud G.A."xsd:string |
| http://purl.uniprot.org/citations/30605519 | http://purl.uniprot.org/core/author | "LeBlanc N."xsd:string |
| http://purl.uniprot.org/citations/30605519 | http://purl.uniprot.org/core/author | "Harquail J."xsd:string |
| http://purl.uniprot.org/citations/30605519 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30605519 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/30605519 | http://purl.uniprot.org/core/pages | "1010-1020"xsd:string |
| http://purl.uniprot.org/citations/30605519 | http://purl.uniprot.org/core/title | "miRNAs 484 and 210 regulate Pax-5 expression and function in breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/30605519 | http://purl.uniprot.org/core/volume | "40"xsd:string |
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