| http://purl.uniprot.org/citations/30606747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30606747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30606747 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular reprogramming leading to induction of Muller glia-derived progenitor cells (MGPCs) with stem cell characteristics is essential for zebrafish retina regeneration. Although several regeneration-specific genes are characterized, the significance of MGPC-associated Mycb induction remains unknown. Here, we show that early expression of Mycb induces expression of genes like ascl1a, a known activator of lin28a in MGPCs. Notably, mycb is simultaneously activated by Ascl1a and repressed by Insm1a in regenerating retina. Here, we unravel a dual role of Mycb in lin28a expression, both as an activator through Ascl1a in MGPCs and a repressor in combination with Hdac1 in neighboring cells. Myc inhibition reduces the number of MGPCs and abolishes normal regeneration. Myc in collaboration with Hdac1 inhibits her4.1, an effector of Delta-Notch signaling. Further, we also show the repressive role of Delta-Notch signaling on lin28a expression in post-injured retina. Our studies reveal mechanistic understanding of Myc pathway during zebrafish retina regeneration, which could pave way for therapeutic intervention during mammalian retina regeneration."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201802113"xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Gupta S."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Gupta S."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Mitra S."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Mitra S."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Ramachandran R."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Ramachandran R."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Sharma P."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Sharma P."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Kaur S."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Kaur S."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Chaudhary M."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Chaudhary M."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Khursheed M.A."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Khursheed M.A."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Kurup A.J."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/author | "Kurup A.J."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/30606747 | http://purl.uniprot.org/core/pages | "489-507"xsd:string |