| http://purl.uniprot.org/citations/30606806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30606806 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene silencing by chromatin compaction is integral to establishing and maintaining cell fates. Trimethylated histone 3 lysine 9 (H3K9me3)-marked heterochromatin is reduced in embryonic stem cells compared to differentiated cells. However, the establishment and dynamics of closed regions of chromatin at protein-coding genes, in embryologic development, remain elusive. We developed an antibody-independent method to isolate and map compacted heterochromatin from low-cell number samples. We discovered high levels of compacted heterochromatin, H3K9me3-decorated, at protein-coding genes in early, uncommitted cells at the germ-layer stage, undergoing profound rearrangements and reduction upon differentiation, concomitant with cell type-specific gene expression. Perturbation of the three H3K9me3-related methyltransferases revealed a pivotal role for H3K9me3 heterochromatin during lineage commitment at the onset of organogenesis and for lineage fidelity maintenance."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aau0583"xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Tan K."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Garcia B.A."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Peng T."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Donahue G."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Sidoli S."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Sheng L."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Bonasio R."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Jenuwein T."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Zaret K.S."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Jain T."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Nicetto D."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Montavon T."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Becker J.S."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Blahnik K."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/author | "Grindheim J.M."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/pages | "294-297"xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/title | "H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification."xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://purl.uniprot.org/core/volume | "363"xsd:string |
| http://purl.uniprot.org/citations/30606806 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30606806 |
| http://purl.uniprot.org/citations/30606806 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30606806 |