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| http://purl.uniprot.org/citations/30606929 | http://www.w3.org/2000/01/rdf-schema#comment | "Adiponectin, the most abundant adipose tissue-derived adipocytokine, improves insulin sensitivity and has anti-inflammatory properties. Disulfide-bond A oxidoreductase-like protein (DsbA-L) is a key molecule in the multimerization of adiponectin (i.e., activation of adiponectin). In mice, liver-specific knockout of the Dsba-L gene impaired the mitochondrial function in hepatocytes and exacerbated the high-fat-diet-induced fatty liver. In addition, the DsbA-L mRNA level is negatively correlated with body mass index (BMI) in humans. We recently investigated the clinical impact of the DsbA-L gene on lifestyle-related diseases in Japanese subjects. We confirmed the influence of the common DsbA-L rs1917760 polymorphism on the multimerization of adiponectin, as well as the association of the polymorphism with the risk of obesity and non-alcoholic fatty liver disease, using prediction models based on a non-linear mixed effect model and/or structural equation models among elderly participants in a health screening program. We also observed a decreasing effect of DsbA-L polymorphism on the DsbA-L mRNA level in peripheral blood mononuclear cells, and an increasing effect of the polymorphism on the prevalence of excessive weight among schizophrenia patients at a high risk for obesity. These findings suggest that DsbA-L may be a key molecule associated with the development and progression of obesity and its related diseases. Therefore, genotyping the DsbA-L polymorphism and identifying patients at a high risk of developing obesity may help prevent obesity and its complications by facilitating targeted prevention and treatment programs for high-risk individuals."xsd:string |
| http://purl.uniprot.org/citations/30606929 | http://purl.org/dc/terms/identifier | "doi:10.1248/yakushi.18-00163-3"xsd:string |
| http://purl.uniprot.org/citations/30606929 | http://purl.uniprot.org/core/author | "Saruwatari J."xsd:string |
| http://purl.uniprot.org/citations/30606929 | http://purl.uniprot.org/core/author | "Oniki K."xsd:string |
| http://purl.uniprot.org/citations/30606929 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30606929 | http://purl.uniprot.org/core/name | "Yakugaku Zasshi"xsd:string |
| http://purl.uniprot.org/citations/30606929 | http://purl.uniprot.org/core/pages | "53-60"xsd:string |
| http://purl.uniprot.org/citations/30606929 | http://purl.uniprot.org/core/title | "[A Multifaceted Approach regarding the Association of the DsbA-L Gene with the Risk of Obesity-related Diseases Based on Clinical Pharmacogenetics]."xsd:string |
| http://purl.uniprot.org/citations/30606929 | http://purl.uniprot.org/core/volume | "139"xsd:string |
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