| http://purl.uniprot.org/citations/30611611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30611611 | http://www.w3.org/2000/01/rdf-schema#comment | "The ability of the immune system to discriminate self from non-self is essential for eradicating microbial pathogens but is also responsible for allograft rejection. Whether it is possible to selectively suppress alloresponses while maintaining anti-pathogen immunity remains unknown. We found that mice deficient in coronin 1, a regulator of naive T cell homeostasis, fully retained allografts while maintaining T cell-specific responses against microbial pathogens. Mechanistically, coronin 1-deficiency increased cyclic adenosine monophosphate (cAMP) concentrations to suppress allo-specific T cell responses. Costimulation induced on microbe-infected antigen presenting cells was able to overcome cAMP-mediated immunosuppression to maintain anti-pathogen immunity. In vivo pharmacological modulation of this pathway or a prior transfer of coronin 1-deficient T cells actively suppressed allograft rejection. These results define a coronin 1-dependent regulatory axis in T cells important for allograft rejection and suggest that modulation of this pathway may be a promising approach to achieve long-term acceptance of mismatched allografts."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2018.12.011"xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Medina E."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Mazumder S."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Stiess M."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Pieters J."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Lang M.J."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Siegmund K."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Ruehl S."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Moshous D."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Fucile G."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Jayachandran R."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Kunz G."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Bumann D."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Hollander G."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Claudi B."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Schmaler M."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Khanna N."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Karrer U."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Rossi S.W."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Bolinger B."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Tchang V."xsd:string |
| http://purl.uniprot.org/citations/30611611 | http://purl.uniprot.org/core/author | "Dertschnig S."xsd:string |