| http://purl.uniprot.org/citations/30613274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30613274 | http://www.w3.org/2000/01/rdf-schema#comment | "Islet α-cell dysfunction has been shown to contribute to type 2 diabetes; however, whether islet α-cell inflammation is involved in the occurrence of pancreatitis is largely unknown. The aims of this study were to investigate how NF-κB inducing kinase (NIK) regulates pancreatic α-cell function, both in vitro and in vivo, and to assess how islet α-cell inflammation induced by NIK affects the development of pancreatitis. Methods: We utilized adenovirus-mediated NIK overexpression, ELISA, qPCR, RNA-seq, and Western blot analyses to study the role of NIK in islet α cells in vitro. Islet α-cell-specific NIK overexpressing (α-NIK-OE) mice were generated, and pancreatic α/β-cell function and the occurrence of pancreatitis in these mice were assessed via ELISA, qPCR, and immunohistochemical analyses. Results: The LTβR/noncanonical NF-κB signaling pathway is present in islet α cells. Overexpression of NIK in αTC1-6 cells induces inflammation and cell death, contributing to a decrease in the expression and secretion of glucagon. Additionally, α-cell specific overexpression of NIK (α-NIK-OE) results in α-cell death, lower serum glucagon levels, and hypoglycemia in mice. Strikingly, α-NIK-OE mice also display a reduced β-cell mass, growth retardation, pancreatitis, and postnatal death. Conclusions: Islet α-cell specific overexpression of NIK results in islet α-cell dysfunction and causes islet β-cell death and pancreatitis, which are most likely due to paracrine secretion of cytokines and chemokines from islet α cells, thus leading to hypoglycemia, growth retardation, and postnatal death in mice."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.org/dc/terms/identifier | "doi:10.7150/thno.28960"xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Dong Y."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Ren X."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Xie L."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Jia L."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Rui L."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Shiota C."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Gittes G.K."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/author | "Dong Y.'"xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/name | "Theranostics"xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/pages | "5960-5971"xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/title | "Islet alpha-cell Inflammation Induced By NF-kappaB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice."xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/30613274 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30613274 |
| http://purl.uniprot.org/citations/30613274 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30613274 |
| http://purl.uniprot.org/uniprot/#_Q3KNY7-mappedCitation-30613274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30613274 |
| http://purl.uniprot.org/uniprot/#_Q544K4-mappedCitation-30613274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30613274 |