| http://purl.uniprot.org/citations/30617255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30617255 | http://www.w3.org/2000/01/rdf-schema#comment | "R-loops are DNA-RNA hybrids enriched at CpG islands (CGIs) that can regulate chromatin states1-8. How R-loops are recognized and interpreted by specific epigenetic readers is unknown. Here we show that GADD45A (growth arrest and DNA damage protein 45A) binds directly to R-loops and mediates local DNA demethylation by recruiting TET1 (ten-eleven translocation 1). Studying the tumor suppressor TCF21 (ref. 9), we find that antisense long noncoding (lncRNA) TARID (TCF21 antisense RNA inducing promoter demethylation) forms an R-loop at the TCF21 promoter. Binding of GADD45A to the R-loop triggers local DNA demethylation and TCF21 expression. TARID transcription, R-loop formation, DNA demethylation, and TCF21 expression proceed sequentially during the cell cycle. Oxidized DNA demethylation intermediates are enriched at genomic R-loops and their levels increase upon RNase H1 depletion. Genomic profiling in embryonic stem cells identifies thousands of R-loop-dependent TET1 binding sites at CGIs. We propose that GADD45A is an epigenetic R-loop reader that recruits the demethylation machinery to promoter CGIs."xsd:string |
| http://purl.uniprot.org/citations/30617255 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41588-018-0306-6"xsd:string |
| http://purl.uniprot.org/citations/30617255 | http://purl.uniprot.org/core/author | "Schafer A."xsd:string |
| http://purl.uniprot.org/citations/30617255 | http://purl.uniprot.org/core/author | "Grummt I."xsd:string |
| http://purl.uniprot.org/citations/30617255 | http://purl.uniprot.org/core/author | "Karaulanov E."xsd:string |
| http://purl.uniprot.org/citations/30617255 | http://purl.uniprot.org/core/author | "Niehrs C."xsd:string |
| http://purl.uniprot.org/citations/30617255 | http://purl.uniprot.org/core/author | "Trnka P."xsd:string |
| http://purl.uniprot.org/citations/30617255 | http://purl.uniprot.org/core/author | "Musheev M."xsd:string |
| http://purl.uniprot.org/citations/30617255 | http://purl.uniprot.org/core/author | "Arab K."xsd:string |
| http://purl.uniprot.org/citations/30617255 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30617255 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/30617255 | http://purl.uniprot.org/core/pages | "217-223"xsd:string |
| http://purl.uniprot.org/citations/30617255 | http://purl.uniprot.org/core/title | "GADD45A binds R-loops and recruits TET1 to CpG island promoters."xsd:string |
| http://purl.uniprot.org/citations/30617255 | http://purl.uniprot.org/core/volume | "51"xsd:string |
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