| http://purl.uniprot.org/citations/30635390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30635390 | http://www.w3.org/2000/01/rdf-schema#comment | "Autoimmune retinopathy (AIR) is a treatable condition that manifests in acute and progressive vision loss in patients. It has recently been determined that AIR is associated with an imbalance of TH1 versus regulatory T cell immunity toward the retinal protein, recoverin. This study describes a new murine model to understand the immunopathology of AIR and its association with T cell responses toward recoverin. Immunization of C57BL/6 mice with recoverin resulted in ocular inflammation including infiltration of CD4+ and CD8+ T lymphocytes, B cells, and CD11b+Ly6C+ inflammatory monocytes in the eyes. Production of IFN-γ and IL-17 from T cells was exacerbated in IL-10 knockout (KO) mice and kinetics of disease development was accelerated. Infiltration of T cells and inflammatory monocytes into the eyes dramatically increased in recoverin-immunized IL-10 KO mice. An immunodominant peptide of recoverin, AG-16, was capable of inducing disease in IL-10 KO mice and resulted in expansion of AG-16 tetramer-specific CD4+ T cells in lymphoid organs and eyes. Adoptive transfer of recoverin-stimulated cells into naive mice was sufficient to induce AIR, and immunization of B cell-deficient mice led to a milder form of the disease. This model supports the hypothesis that recoverin-specific T cell responses are major drivers of AIR pathogenesis and that IL-10 is an important factor in protection."xsd:string |
| http://purl.uniprot.org/citations/30635390 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1800574"xsd:string |
| http://purl.uniprot.org/citations/30635390 | http://purl.uniprot.org/core/author | "Heckenlively J.R."xsd:string |
| http://purl.uniprot.org/citations/30635390 | http://purl.uniprot.org/core/author | "Lin C.M."xsd:string |
| http://purl.uniprot.org/citations/30635390 | http://purl.uniprot.org/core/author | "Lundy S.K."xsd:string |
| http://purl.uniprot.org/citations/30635390 | http://purl.uniprot.org/core/author | "Nikoopour E."xsd:string |
| http://purl.uniprot.org/citations/30635390 | http://purl.uniprot.org/core/author | "Sheskey S."xsd:string |
| http://purl.uniprot.org/citations/30635390 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30635390 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/30635390 | http://purl.uniprot.org/core/pages | "1057-1068"xsd:string |
| http://purl.uniprot.org/citations/30635390 | http://purl.uniprot.org/core/title | "Immune Cell Infiltration into the Eye Is Controlled by IL-10 in Recoverin-Induced Autoimmune Retinopathy."xsd:string |
| http://purl.uniprot.org/citations/30635390 | http://purl.uniprot.org/core/volume | "202"xsd:string |
| http://purl.uniprot.org/citations/30635390 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30635390 |
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