| http://purl.uniprot.org/citations/30639412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30639412 | http://www.w3.org/2000/01/rdf-schema#comment | "Atherosclerosis is a chronic disorder of the vessel wall. One key regulator of disease progression is lipid handling in macrophages. However, the role of macrophage mitochondrial-dependent fatty acid β-oxidation (FAO) in atherosclerosis is not well defined. To address this, we focused on carnitine palmitoyltransferase (CPT) 1 and 2, which play an essential role in the transport of long chain fatty acids (FAs) into the mitochondria. Using conditional alleles of these mitochondrial enzymes, we have generated myeloid-specific Cpt1a and Cpt2 knockout mutants (CPT1a M-KO and CPT2 M-KO). In culture, macrophages derived from CPT1a and CPT2 M-KO mice have impaired FAO, enhanced expression of the CD36 scavenger receptor, increased uptake of oxidized low-density lipoprotein (oxLDL), and augmented transformation into cholesterol-rich foam cells. In line with these in vitro observations, in the atherosclerosis-susceptible apolipoprotein E (ApoE) KO background, CPT2 M-KO mice demonstrated augmented atherosclerosis, accompanied by increased accumulation of aortic macrophages with elevated CD36 expression. These data suggest that macrophage FAO is athero-protective and that augmenting FAO may potentially slow atherosclerotic progression."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yjmcc.2019.01.003"xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/author | "Nomura M."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/author | "Yan Y."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/author | "Yamazaki T."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/author | "Wolfgang M.J."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/author | "Finkel T."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/author | "Rovira I.I."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/author | "Kawagishi H."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/author | "Yu Z.X."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/author | "Mukouyama Y.S."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/name | "J Mol Cell Cardiol"xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/pages | "270-276"xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/title | "Macrophage fatty acid oxidation inhibits atherosclerosis progression."xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/30639412 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30639412 |
| http://purl.uniprot.org/citations/30639412 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30639412 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-30639412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30639412 |
| http://purl.uniprot.org/uniprot/#_P52825-mappedCitation-30639412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30639412 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GX15-mappedCitation-30639412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30639412 |
| http://purl.uniprot.org/uniprot/#_A2A8E7-mappedCitation-30639412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30639412 |