| http://purl.uniprot.org/citations/30642431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30642431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30642431 | http://www.w3.org/2000/01/rdf-schema#comment | "Animals respond to mitochondrial stress with the induction of mitochondrial unfolded protein response (UPRmt). A cascade of events occur upon UPRmt activation, ultimately triggering a transcriptional response governed by two transcription factors: DVE-1 and ATFS-1. Here we identify SUMO-specific peptidase ULP-4 as a positive regulator of C. elegans UPRmt to control SUMOylation status of DVE-1 and ATFS-1. SUMOylation affects these two axes in the transcriptional program of UPRmt with distinct mechanisms: change of DVE-1 subcellular localization vs. change of ATFS-1 stability and activity. Our findings reveal a post-translational modification that promotes immune response and lifespan extension during mitochondrial stress."xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.41792"xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.41792"xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/author | "Hu S."xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/author | "Hu S."xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/author | "Gao K."xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/author | "Gao K."xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/title | "SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension."xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/title | "SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension."xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/30642431 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30642431 |
| http://purl.uniprot.org/citations/30642431 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30642431 |
| http://purl.uniprot.org/citations/30642431 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30642431 |
| http://purl.uniprot.org/citations/30642431 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30642431 |