| http://purl.uniprot.org/citations/30642977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30642977 | http://www.w3.org/2000/01/rdf-schema#comment | "The ICOS pathway has been implicated in the development and functions of regulatory T (Treg) cells, including those producing IL-10. Treg cell-derived IL-10 is indispensable for the establishment and maintenance of intestinal immune homeostasis. We examined the possible involvement of the ICOS pathway in the accumulation of murine colonic Foxp3-and/or IL-10-expressing cells. We show that ICOS deficiency does not impair induction of IL-10 by intestinal CD4 T cells but, instead, triggers substantial reductions in gut-resident and peripherally derived Foxp3+ Treg cells. ICOS deficiency is associated with reduced demethylation of Foxp3 CNS2 and enhanced loss of Foxp3. This instability significantly limits the ability of ICOS-deficient Treg cells to reverse ongoing inflammation. Collectively, our results identify a novel role for ICOS costimulation in imprinting the functional stability of Foxp3 that is required for the retention of full Treg cell function in the periphery."xsd:string |
| http://purl.uniprot.org/citations/30642977 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1801266"xsd:string |
| http://purl.uniprot.org/citations/30642977 | http://purl.uniprot.org/core/author | "Schoeb T.R."xsd:string |
| http://purl.uniprot.org/citations/30642977 | http://purl.uniprot.org/core/author | "Klocke B.J."xsd:string |
| http://purl.uniprot.org/citations/30642977 | http://purl.uniprot.org/core/author | "Maynard C.L."xsd:string |
| http://purl.uniprot.org/citations/30642977 | http://purl.uniprot.org/core/author | "Landuyt A.E."xsd:string |
| http://purl.uniprot.org/citations/30642977 | http://purl.uniprot.org/core/author | "Colvin T.B."xsd:string |
| http://purl.uniprot.org/citations/30642977 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30642977 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/30642977 | http://purl.uniprot.org/core/pages | "1039-1044"xsd:string |
| http://purl.uniprot.org/citations/30642977 | http://purl.uniprot.org/core/title | "Cutting Edge: ICOS-Deficient Regulatory T Cells Display Normal Induction of Il10 but Readily Downregulate Expression of Foxp3."xsd:string |
| http://purl.uniprot.org/citations/30642977 | http://purl.uniprot.org/core/volume | "202"xsd:string |
| http://purl.uniprot.org/citations/30642977 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30642977 |
| http://purl.uniprot.org/citations/30642977 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30642977 |
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| http://purl.uniprot.org/uniprot/#_P15919-mappedCitation-30642977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30642977 |
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