| http://purl.uniprot.org/citations/30651296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30651296 | http://www.w3.org/2000/01/rdf-schema#comment | "Organ growth and tissue homeostasis rely on the proliferation and differentiation of progenitor cell populations. In the developing lung, localized Fgf10 expression maintains distal Sox9-expressing epithelial progenitors and promotes basal cell differentiation in the cartilaginous airways. Mesenchymal Fgf10 expression is induced by Wnt signaling but inhibited by Shh signaling, and epithelial Fgf10 signaling activates β-catenin signaling. The Hippo pathway is a well-conserved signaling cascade that regulates organ size and stem/progenitor cell behavior. Here, we show that Hippo signaling promotes lineage commitment of lung epithelial progenitors by curbing Fgf10 and β-catenin signaling. Our findings show that both inactivation of the Hippo pathway (nuclear Yap) or ablation of Yap result in increased β-catenin and Fgf10 signaling, suggesting a cytoplasmic role for Yap in epithelial lineage commitment. We further demonstrate redundant and non-redundant functions for the two nuclear effectors of the Hippo pathway, Yap and Taz, during lung development."xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.166454"xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/author | "Yuan T."xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/author | "Zhang J.S."xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/author | "Fassler R."xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/author | "Hopkins S."xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/author | "Thannickal V.J."xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/author | "De Langhe S.P."xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/author | "Volckaert T."xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/author | "Boateng E."xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/pages | "dev166454"xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/title | "Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://purl.uniprot.org/core/volume | "146"xsd:string |
| http://purl.uniprot.org/citations/30651296 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30651296 |
| http://purl.uniprot.org/citations/30651296 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30651296 |
| http://purl.uniprot.org/uniprot/#_D3Z7K2-mappedCitation-30651296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30651296 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-30651296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30651296 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNZ0-mappedCitation-30651296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30651296 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNG0-mappedCitation-30651296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30651296 |
| http://purl.uniprot.org/uniprot/#_D3Z5M8-mappedCitation-30651296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30651296 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-30651296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30651296 |