| http://purl.uniprot.org/citations/30661930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30661930 | http://www.w3.org/2000/01/rdf-schema#comment | "Metabolic reprogramming plays an important role in supporting tumor growth. However, little is known about the metabolic alterations that promote cancer metastasis. In this study, we identify acyl-CoA thioesterase 12 (ACOT12) as a key player in hepatocellular carcinoma (HCC) metastasis. The expression of ACOT12 is significantly down-regulated in HCC tissues and is closely associated with HCC metastasis and poor survival of HCC patients. Gain- and loss-of-function studies demonstrate that ACOT12 suppresses HCC metastasis both in vitro and in vivo. Further mechanistic studies reveal that ACOT12 regulates the cellular acetyl-CoA levels and histone acetylation in HCC cells and that down-regulation of ACOT12 promotes HCC metastasis by epigenetically inducing TWIST2 expression and the promotion of epithelial-mesenchymal transition. Taken together, our findings link the alteration of acetyl-CoA with HCC metastasis and imply that ACOT12 could be a prognostic marker and a potential therapeutic target for combating HCC metastasis."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2018.12.019"xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Chen J.H."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Lu M."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Wang S.H."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Wang L.X."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Lu J.Q."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Tang J.J."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Qin L.X."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Yu G.Y."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Lin Z.F."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Jia H.L."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Zhang K.L."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Dong Q.Z."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Zhu W.W."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/author | "Shao W.Q."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/pages | "886-900.e5"xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/title | "ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition."xsd:string |
| http://purl.uniprot.org/citations/30661930 | http://purl.uniprot.org/core/volume | "29"xsd:string |