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| http://purl.uniprot.org/citations/30668272 | http://www.w3.org/2000/01/rdf-schema#comment | "Drosophila melanogaster has recently been developed as a simple, in vivo, genetic model of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent cisplatin display both a neurodegenerative phenotype and cell death in rapidly dividing follicles, mimicking the cell specific responses seen in humans. Cisplatin induces climbing deficiencies and loss of fertility in a dose dependent manner. Drosophila sensitivity to cisplatin in both cell types is affected by genetic background. We show that mutation or RNAi-based knockdown of genes known to be associated with CIPN incidence in humans affect sensitivity of flies to CIPN. Drosophila is a promising model with which to study the effect of genetics on sensitivity to CIPN."xsd:string |
| http://purl.uniprot.org/citations/30668272 | http://purl.org/dc/terms/identifier | "doi:10.1080/19336934.2019.1565257"xsd:string |
| http://purl.uniprot.org/citations/30668272 | http://purl.uniprot.org/core/author | "Windebank A.J."xsd:string |
| http://purl.uniprot.org/citations/30668272 | http://purl.uniprot.org/core/author | "Podratz J.L."xsd:string |
| http://purl.uniprot.org/citations/30668272 | http://purl.uniprot.org/core/author | "Groen C.M."xsd:string |
| http://purl.uniprot.org/citations/30668272 | http://purl.uniprot.org/core/author | "Treb K."xsd:string |
| http://purl.uniprot.org/citations/30668272 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30668272 | http://purl.uniprot.org/core/name | "Fly (Austin)"xsd:string |
| http://purl.uniprot.org/citations/30668272 | http://purl.uniprot.org/core/pages | "174-182"xsd:string |
| http://purl.uniprot.org/citations/30668272 | http://purl.uniprot.org/core/title | "Drosophila strain specific response to cisplatin neurotoxicity."xsd:string |
| http://purl.uniprot.org/citations/30668272 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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