| http://purl.uniprot.org/citations/30673607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30673607 | http://www.w3.org/2000/01/rdf-schema#comment | "Notch is a conserved signaling pathway that is essential for metazoan development and homeostasis; dysregulated signaling underlies the pathophysiology of numerous human diseases. Receptor-ligand interactions result in gene expression changes, which are regulated by the transcription factor RBPJ. RBPJ forms a complex with the intracellular domain of the Notch receptor and the coactivator Mastermind to activate transcription, but it can also function as a repressor by interacting with corepressor proteins. Here, we determine the structure of RBPJ bound to the corepressor SHARP and DNA, revealing its mode of binding to RBPJ. We tested structure-based mutants in biophysical and biochemical-cellular assays to characterize the role of RBPJ as a repressor, clearly demonstrating that RBPJ mutants deficient for SHARP binding are incapable of repressing transcription of genes responsive to Notch signaling in cells. Altogether, our structure-function studies provide significant insights into the repressor function of RBPJ."xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.12.097"xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/author | "Pan L."xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/author | "Yuan Z."xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/author | "Borggrefe T."xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/author | "Hein K."xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/author | "Oswald F."xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/author | "Giaimo B.D."xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/author | "Kovall R.A."xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/author | "Collins C.E."xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/author | "VanderWielen B.D."xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/author | "Turkiewicz A."xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/pages | "845-854.e6"xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/title | "Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site."xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/30673607 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30673607 |
| http://purl.uniprot.org/citations/30673607 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30673607 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTV5-mappedCitation-30673607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30673607 |
| http://purl.uniprot.org/uniprot/#_P0AEX9-mappedCitation-30673607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30673607 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YVE0-mappedCitation-30673607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30673607 |
| http://purl.uniprot.org/uniprot/#_A0N920-mappedCitation-30673607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30673607 |
| http://purl.uniprot.org/uniprot/#_A2ADB0-mappedCitation-30673607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30673607 |