| http://purl.uniprot.org/citations/30675988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30675988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30675988 | http://www.w3.org/2000/01/rdf-schema#comment | "Life relies on a myriad of carefully orchestrated processes, in which proteins and their direct interplay ultimately determine cellular function and disease. Modulation of this complex crosstalk has recently attracted attention, even as a novel therapeutic strategy. Herein, we describe the synthesis and characterization of two visible-light-responsive peptide backbone photoswitches based on azobenzene derivatives, to exert optical control over protein-protein interactions (PPI). The novel peptidomimetics undergo fast and reversible isomerization with low photochemical fatigue under alternatively blue-/green-light irradiation cycles. Both bind in the nanomolar range to the protein of interest. Importantly, the best peptidomimetic displays a clear difference between isomers in its protein-binding capacity and, in turn, in its potential to inhibit enzymatic activity through PPI disruption. In addition, crystal structure determination, docking and molecular dynamics calculations allow a molecular interpretation and open up new avenues in the design and synthesis of future photoswitchable PPI modulators."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbic.201800737"xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbic.201800737"xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Dou Y."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Dou Y."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Essen L.O."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Essen L.O."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Albert L."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Albert L."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Djokovic N."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Djokovic N."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Hoffarth M."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Hoffarth M."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Nikolic K."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Nikolic K."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Penalver A."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Penalver A."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Ruzic D."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Ruzic D."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Vazquez O."xsd:string |
| http://purl.uniprot.org/citations/30675988 | http://purl.uniprot.org/core/author | "Vazquez O."xsd:string |