| http://purl.uniprot.org/citations/30677741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30677741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30677741 | http://www.w3.org/2000/01/rdf-schema#comment | "The human mitochondrial translational initiation factor 3 (IF3mt) carries mitochondrial-specific amino acid extensions at both its N and C termini (N- and C-terminal extensions [NTE and CTE, respectively]), when compared with its eubacterial counterpart. Here we present 3.3-to 3.5-Å-resolution cryoelectron microscopic structures of the mammalian 28S mitoribosomal subunit in complex with human IF3mt. Unique contacts observed between the 28S subunit and N-terminal domain of IF3mt explain its unusually high affinity for the 28S subunit, whereas the position of the mito-specific NTE suggests NTE's role in binding of initiator tRNA to the 28S subunit. The location of the C-terminal domain (CTD) clarifies its anti-association activity, whereas the orientation of the mito-specific CTE provides a mechanistic explanation for its role in destabilizing initiator tRNA in the absence of mRNA. Furthermore, our structure hints at a possible role of the CTD in recruiting leaderless mRNAs for translation initiation. Our findings highlight unique features of IF3mt in mitochondrial translation initiation."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2018.12.030"xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2018.12.030"xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/author | "Spremulli L.L."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/author | "Spremulli L.L."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/author | "Haque M.E."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/author | "Haque M.E."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/author | "Agrawal R.K."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/author | "Agrawal R.K."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/author | "Sharma M.R."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/author | "Sharma M.R."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/author | "Koripella R.K."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/author | "Koripella R.K."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/author | "Risteff P."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/author | "Risteff P."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/name | "IScience"xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/pages | "76-86"xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/pages | "76-86"xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/title | "Structure of Human Mitochondrial Translation Initiation Factor 3 Bound to the Small Ribosomal Subunit."xsd:string |
| http://purl.uniprot.org/citations/30677741 | http://purl.uniprot.org/core/title | "Structure of Human Mitochondrial Translation Initiation Factor 3 Bound to the Small Ribosomal Subunit."xsd:string |