| http://purl.uniprot.org/citations/30679689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30679689 | http://www.w3.org/2000/01/rdf-schema#comment | "Ceramides are sphingolipids with defined acyl chain lengths, which are produced by corresponding ceramide synthases (CerS1-6). In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), the ablation of CerS2 suppresses EAE-pathology by reducing neutrophil migration into the central nervous system. This migration is induced by granulocyte-colony stimulating factor (G-CSF) signaling. G-CSF signaling leads to a signal cascade including the phosphorylation of Lyn kinase and STAT3. This in turn regulates expression of the neutrophil surface receptor chemokine receptor 2 (CXCR2) and causes translocation of the receptor into detergent-resistant membranes (DRMs). In this study we investigated the role of ceramides in G-CSF signaling. We found, that G-CSF treatment of wild type bone marrow cells (BMCs) leads to translocation of G-CSF-receptor (G-CSF-R) into DRMs. G-CSF also induces downregulation of ceramides in WT and CerS2 null BMCs, as well as upregulation of very long chain lactosylceramides. However, in CerS2 null BMCs, G-CSF failed to induce translocation of G-CSF-R into DRMs, leading to reduced phosphorylation of Lyn and reduced CXCR2 expression. Interestingly, G-CSF signaling in CerS6 null BMCs was not affected. In conclusion, very long chain ceramides are important for G-CSF signaling and translocation of G-CSF-R into DRMs."xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-37342-8"xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/author | "Schiffmann S."xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/author | "Geisslinger G."xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/author | "Ferreiros N."xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/author | "Kurz J."xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/author | "Blum L."xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/author | "Grosch S."xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/author | "Wegner M.S."xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/author | "Barthelmes J."xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/author | "Ulshofer T."xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/author | "Roser L."xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/pages | "747"xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/title | "Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes."xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30679689 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30679689 |
| http://purl.uniprot.org/citations/30679689 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30679689 |
| http://purl.uniprot.org/uniprot/#_D3Z0Z2-mappedCitation-30679689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30679689 |
| http://purl.uniprot.org/uniprot/#_Q0VB73-mappedCitation-30679689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30679689 |
| http://purl.uniprot.org/uniprot/#_D3YTM0-mappedCitation-30679689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30679689 |
| http://purl.uniprot.org/uniprot/#_D3Z4M2-mappedCitation-30679689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30679689 |
| http://purl.uniprot.org/uniprot/#_P40223-mappedCitation-30679689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30679689 |