| http://purl.uniprot.org/citations/30683688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30683688 | http://www.w3.org/2000/01/rdf-schema#comment | "Stimulator of interferon genes (STING) plays a key role in detecting cytosolic DNA and induces type I interferon (IFN-I) responses for host defense against pathogens. Although T cells highly express STING, its physiological role remains unknown. Here, we show that costimulation of T cells with the STING ligand cGAMP and TCR leads to IFN-I production and strongly inhibits T-cell growth. TCR-mediated mTORC1 activation and sustained activation of IRF3 are required for cGAMP-induced IFN-I production, and the mTORC1 activity is partially counteracted by cGAMP, thereby blocking proliferation. This mTORC1 inhibition in response to costimulation depends on IRF3 and IRF7. Effector T cells produce much higher IFN-I levels than innate cells in response to cGAMP. Finally, we demonstrated that STING stimulation in T cells is effective in inducing antitumor responses in vivo. Our studies demonstrate that the outputs of STING and TCR signaling pathways are mutually regulated through mTORC1 to modulate T-cell functions."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.org/dc/terms/identifier | "doi:10.26508/lsa.201800282"xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Arita M."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Ikeda K."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Imanishi T."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Matsuda S."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Miyake K."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Unno M."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Kobayashi W."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Hoshii T."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Barber G.N."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Ishii K.J."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Hirao A."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/author | "Yoneda N."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/name | "Life Sci Alliance"xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/pages | "e201800282"xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/title | "Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function."xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/30683688 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30683688 |
| http://purl.uniprot.org/citations/30683688 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30683688 |
| http://purl.uniprot.org/uniprot/#_A0A125R9I3-mappedCitation-30683688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30683688 |