| http://purl.uniprot.org/citations/30683702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30683702 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-17A is a critical proinflammatory cytokine for the pathogenesis of asthma including neutrophilic pulmonary inflammation and airway hyperresponsiveness. In this study, by cell type-specific deletion of IL-17R and adaptor Act1, we demonstrated that IL-17R/Act1 exerts a direct impact on the contraction of airway smooth muscle cells (ASMCs). Mechanistically, IL-17A induced the recruitment of Rab35 (a small monomeric GTPase) and DennD1C (guanine nucleotide exchange factor [GEF]) to the IL-17R/Act1 complex in ASMCs, resulting in activation of Rab35. Rab35 knockdown showed that IL-17A-induced Rab35 activation was essential for protein kinase Cα (PKCα) activation and phosphorylation of fascin at Ser39 in ASMCs, allowing F-actin to interact with myosin to form stress fibers and enhance the contraction induced by methacholine. PKCα inhibitor or Rab35 knockdown indeed substantially reduced IL-17A-induced stress fiber formation in ASMCs and attenuated IL-17A-enhanced, methacholine-induced contraction of airway smooth muscle. Taken together, these data indicate that IL-17A promotes airway smooth muscle contraction via direct recruitment of Rab35 to IL-17R, followed by PKCα activation and stress fiber formation."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1801025"xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Gao J."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Ouyang S."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Sheppard D."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Echard A."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Sundaram A."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Bulek K."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Aronica M."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Garantziotis S."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Carman J."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Dongre A."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Herjan T."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Zepp J."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Majors A."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Bodaszewska-Lubas M."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/author | "Parron V."xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/pages | "1540-1548"xsd:string |
| http://purl.uniprot.org/citations/30683702 | http://purl.uniprot.org/core/title | "IL-17A Recruits Rab35 to IL-17R to Mediate PKCalpha-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility."xsd:string |