http://purl.uniprot.org/citations/30689541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/30689541 | http://www.w3.org/2000/01/rdf-schema#comment | "Midbrain dopaminergic (mDA) neurons migrate to form the laterally-located substantia nigra pars compacta (SN) and medially-located ventral tegmental area (VTA), but little is known about the underlying cellular and molecular processes. Here we visualize the dynamic cell morphologies of tangentially migrating SN-mDA neurons in 3D and identify two distinct migration modes. Slow migration is the default mode in SN-mDA neurons, while fast, laterally-directed migration occurs infrequently and is strongly associated with bipolar cell morphology. Tangential migration of SN-mDA neurons is altered in absence of Reelin signaling, but it is unclear whether Reelin acts directly on migrating SN-mDA neurons and how it affects their cell morphology and migratory behavior. By specifically inactivating Reelin signaling in mDA neurons we demonstrate its direct role in SN-mDA tangential migration. Reelin promotes laterally-biased movements in mDA neurons during their slow migration mode, stabilizes leading process morphology and increases the probability of fast, laterally-directed migration."xsd:string |
http://purl.uniprot.org/citations/30689541 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.41623"xsd:string |
http://purl.uniprot.org/citations/30689541 | http://purl.uniprot.org/core/author | "Blaess S."xsd:string |
http://purl.uniprot.org/citations/30689541 | http://purl.uniprot.org/core/author | "Hagemann C."xsd:string |
http://purl.uniprot.org/citations/30689541 | http://purl.uniprot.org/core/author | "Brustle O."xsd:string |
http://purl.uniprot.org/citations/30689541 | http://purl.uniprot.org/core/author | "Fried H.U."xsd:string |
http://purl.uniprot.org/citations/30689541 | http://purl.uniprot.org/core/author | "Weykopf B."xsd:string |
http://purl.uniprot.org/citations/30689541 | http://purl.uniprot.org/core/author | "Vaswani A.R."xsd:string |
http://purl.uniprot.org/citations/30689541 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
http://purl.uniprot.org/citations/30689541 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
http://purl.uniprot.org/citations/30689541 | http://purl.uniprot.org/core/pages | "e41623"xsd:string |
http://purl.uniprot.org/citations/30689541 | http://purl.uniprot.org/core/title | "Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons."xsd:string |
http://purl.uniprot.org/citations/30689541 | http://purl.uniprot.org/core/volume | "8"xsd:string |
http://purl.uniprot.org/citations/30689541 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30689541 |
http://purl.uniprot.org/citations/30689541 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30689541 |
http://purl.uniprot.org/uniprot/#_D3Z7L5-mappedCitation-30689541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30689541 |
http://purl.uniprot.org/uniprot/#_A0A0A0MQI4-mappedCitation-30689541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30689541 |
http://purl.uniprot.org/uniprot/#_A0A0U1RNW8-mappedCitation-30689541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30689541 |
http://purl.uniprot.org/uniprot/#_A0A0U1RPC1-mappedCitation-30689541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30689541 |
http://purl.uniprot.org/uniprot/#_E9Q9G5-mappedCitation-30689541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30689541 |
http://purl.uniprot.org/uniprot/#_A0A0R4J239-mappedCitation-30689541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30689541 |
http://purl.uniprot.org/uniprot/#_A0A0U1RNH0-mappedCitation-30689541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30689541 |
http://purl.uniprot.org/uniprot/#_A0A0U1RNI3-mappedCitation-30689541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30689541 |
http://purl.uniprot.org/uniprot/#_D3Z581-mappedCitation-30689541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30689541 |