| http://purl.uniprot.org/citations/30690734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30690734 | http://www.w3.org/2000/01/rdf-schema#comment | "T helper type 17 lymphocytes (Th17 cells) infiltrate the central nervous system (CNS), induce inflammation and demyelination and play a pivotal role in the pathogenesis of multiple sclerosis. Sialomucin CD43 is highly expressed in Th17 cells and mediates adhesion to endothelial selectin (E-selectin), an initiating step in Th17 cell recruitment to sites of inflammation. CD43-/- mice have impaired Th17 cell recruitment to the CNS and are protected from experimental autoimmune encephalomyelitis (EAE), the mouse model of multiple sclerosis. However, E-selectin is dispensable for the development of EAE, in contrast to intercellular and vascular cell adhesion molecules (ICAM-1 and VCAM-1). We report that CD43-/- mice have decreased demyelination and T-cell infiltration, but similar up-regulation of ICAM-1 and VCAM-1 in the spinal cord, compared with wild-type (WT) mice, at the initiation of EAE. CD43-/- Th17 cells have impaired adhesion to ICAM-1 under flow conditions in vitro, despite having similar expression of LFA-1, the main T-cell ligand for ICAM-1, as WT Th17 cells. Regardless of the route of integrin activation, CD43-/- Th17 cell firm arrest on ICAM-1 was comparable to that of WT Th17 cells, but CD43-/- Th17 cells failed to optimally apically migrate on immobilized ICAM-1-coated coverslips and endothelial cells, and to transmigrate under shear flow conditions in an ICAM-1-dependent manner. Collectively, these findings unveil novel roles for CD43, facilitating adhesion of Th17 cells to ICAM-1 and modulating apical and transendothelial migration, as mechanisms potentially responsible for Th17 cell recruitment to sites of inflammation such as the CNS."xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://purl.org/dc/terms/identifier | "doi:10.1111/imm.13047"xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://purl.uniprot.org/core/author | "Alcaide P."xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://purl.uniprot.org/core/author | "Ngwenyama N."xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://purl.uniprot.org/core/author | "Nevers T."xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://purl.uniprot.org/core/author | "Salvador A.M."xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://purl.uniprot.org/core/author | "Carrillo-Salinas F.J."xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://purl.uniprot.org/core/author | "Anastasiou M."xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://purl.uniprot.org/core/author | "Velazquez F.E."xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30690734 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://purl.uniprot.org/core/pages | "52-69"xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://purl.uniprot.org/core/title | "Sialomucin CD43 regulates T helper type 17 cell intercellular adhesion molecule 1 dependent adhesion, apical migration and transendothelial migration."xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://purl.uniprot.org/core/volume | "157"xsd:string |
| http://purl.uniprot.org/citations/30690734 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30690734 |
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