| http://purl.uniprot.org/citations/30692525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30692525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30692525 | http://www.w3.org/2000/01/rdf-schema#comment | "Domain swapping is the process by which identical monomeric proteins exchange structural elements to generate dimers/oligomers. Although engineered domain swapping is a compelling strategy for protein assembly, its application has been limited due to the lack of simple and reliable design approaches. Here, we demonstrate that the hydrophobic five-residue 'cystatin motif' (QVVAG) from the domain-swapping protein Stefin B, when engineered into a solvent-exposed, tight surface loop between two β-strands prevents the loop from folding back upon itself, and drives domain swapping in non-domain-swapping proteins. High-resolution structural studies demonstrate that engineering the QVVAG stretch independently into various surface loops of four structurally distinct non-domain-swapping proteins enabled the design of different modes of domain swapping in these proteins, including single, double and open-ended domain swapping. These results suggest that the introduction of the QVVAG motif can be used as a mutational approach for engineering domain swapping in diverse β-hairpin proteins."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-08295-x"xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-08295-x"xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Das R."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Das R."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Negi H."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Negi H."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Surana P."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Surana P."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Gosavi S."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Gosavi S."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Mascarenhas N.M."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Mascarenhas N.M."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Nandwani N."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Nandwani N."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Udgaonkar J.B."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/author | "Udgaonkar J.B."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/pages | "452"xsd:string |
| http://purl.uniprot.org/citations/30692525 | http://purl.uniprot.org/core/pages | "452"xsd:string |