| http://purl.uniprot.org/citations/30692621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30692621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30692621 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammatory caspases (caspase-1, caspase-4, caspase-5 and caspase-11 (caspase-1/-4/-5/-11)) mediate host defense against microbial infections, processing pro-inflammatory cytokines and triggering pyroptosis. However, precise checkpoints are required to prevent their unsolicited activation. Here we report that serpin family B member 1 (SERPINB1) limited the activity of those caspases by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. While the reactive center loop of SERPINB1 inhibits neutrophil serine proteases, its carboxy-terminal CARD-binding motif restrained the activation of pro-caspase-1/-4/-5/-11. Consequently, knockdown or deletion of SERPINB1 prompted spontaneous activation of caspase-1/-4/-5/-11, release of the cytokine IL-1β and pyroptosis, inducing elevated inflammation after non-hygienic co-housing with pet-store mice and enhanced sensitivity to lipopolysaccharide- or Acinetobacter baumannii-induced endotoxemia. Our results reveal that SERPINB1 acts as a vital gatekeeper of inflammation by restraining neutrophil serine proteases and inflammatory caspases in a genetically and functionally separable manner."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41590-018-0303-z"xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41590-018-0303-z"xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Lee H.R."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Lee H.R."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Lu A."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Lu A."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Jung J.U."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Jung J.U."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Choi Y.J."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Choi Y.J."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Ruan J."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Ruan J."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Spellberg B."xsd:string |
| http://purl.uniprot.org/citations/30692621 | http://purl.uniprot.org/core/author | "Spellberg B."xsd:string |