| http://purl.uniprot.org/citations/30710047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30710047 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunonutrition as a therapeutic approach is rapidly gaining interest in the fight against infection. Targeting l-arginine metabolism is intriguing, considering this amino acid is the substrate for antimicrobial NO production by macrophages. The importance of l-arginine during infection is supported by the finding that inhibiting its synthesis from its precursor l-citrulline blunts host defense. During the first few weeks following pulmonary mycobacterial infection, we found a drastic increase in l-citrulline in the lung, even though serum concentrations were unaltered. This correlated with increased gene expression of the l-citrulline-generating (i.e., iNOS) and l-citrulline-using (i.e., Ass1) enzymes in key myeloid populations. Eliminating l-arginine synthesis from l-citrulline in myeloid cells via conditional deletion of either Ass1 or Asl resulted in increased Mycobacterium bovis bacillus Calmette-Guérin and Mycobacterium tuberculosis H37Rv burden in the lungs compared with controls. Our data illustrate the necessity of l-citrulline metabolism for myeloid defense against mycobacterial infection and highlight the potential for host-directed therapy against mycobacterial disease targeting this nutrient and/or its metabolic pathway."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1801569"xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/author | "Setchell K.D.R."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/author | "Qualls J.E."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/author | "Schmidt S.M."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/author | "Arnett E."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/author | "Schlesinger L.S."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/author | "Lange S.M."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/author | "McKell M.C."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/author | "Green L.C."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/author | "Kohler S.E."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/author | "Bricker R.L."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/author | "Crowther R.R."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/pages | "1747-1754"xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/title | "l-Arginine Synthesis from l-Citrulline in Myeloid Cells Drives Host Defense against Mycobacteria In Vivo."xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://purl.uniprot.org/core/volume | "202"xsd:string |
| http://purl.uniprot.org/citations/30710047 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30710047 |
| http://purl.uniprot.org/citations/30710047 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30710047 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-30710047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30710047 |
| http://purl.uniprot.org/uniprot/#_E0CY49-mappedCitation-30710047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30710047 |
| http://purl.uniprot.org/uniprot/#_E0CYV3-mappedCitation-30710047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30710047 |