| http://purl.uniprot.org/citations/30710084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30710084 | http://www.w3.org/2000/01/rdf-schema#comment | "Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the genetic contribution to efficient weight loss in response to dietary intervention remains unknown. We perform a GWAS in two large low-caloric diet intervention cohorts of obese participants. Two loci close to NKX6.3/MIR486 and RBSG4 are identified in the Canadian discovery cohort (n = 1166) and replicated in the DiOGenes cohort (n = 789). Modulation of HGTX (NKX6.3 ortholog) levels in Drosophila melanogaster leads to significantly altered triglyceride levels. Additional tissue-specific experiments demonstrate an action through the oenocytes, fly hepatocyte-like cells that regulate lipid metabolism. Our results identify genetic variants associated with the efficacy of weight loss in obese subjects and identify a role for NKX6.3 in lipid metabolism, and thereby possibly weight control."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-08492-8"xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Dent R."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Harper M.E."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Neely G.G."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Langin D."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Lefebvre G."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Clark T."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Gheldof N."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Hager J."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Valsesia A."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Wang Q.P."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Lau P."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Walter O."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Descombes P."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Astrup A."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Chabert C."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Carayol J."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Viguerie N."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Mironova P."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Saris W.H."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Metairon S."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Oyston L.J."xsd:string |
| http://purl.uniprot.org/citations/30710084 | http://purl.uniprot.org/core/author | "Ruffieux H."xsd:string |