| http://purl.uniprot.org/citations/30716474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30716474 | http://www.w3.org/2000/01/rdf-schema#comment | "Erythropoietin (EPO) is a secreted hormone that stimulates the production of red blood cells, and the level of EPO is increased under hypoxia. The expression of EPO is regulated not only by the hypoxia-inducible factor (HIF) but also partly through epigenetic modifications, including histone acetylation and methylation. In this study, we report that histone H3K9 demethylase JMJD1 A is regulated by HIF-2α in HepG2 cells under hypoxia. Knockdown or over-expression of JMJD1 A can decrease or increase EPO expression, respectively. JMJD1 A can interact with HIF-2α to form a co-activator complex, which binds to the hypoxia response elements of EPO and increases EPO expression by catalyzing demethylation of H3K9me2, a transcription suppression marker. The results demonstrate that JMJD1 A is a co-activator of EPO expression."xsd:string |
| http://purl.uniprot.org/citations/30716474 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biocel.2019.01.022"xsd:string |
| http://purl.uniprot.org/citations/30716474 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/30716474 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/30716474 | http://purl.uniprot.org/core/author | "Tian Z."xsd:string |
| http://purl.uniprot.org/citations/30716474 | http://purl.uniprot.org/core/author | "Yao L."xsd:string |
| http://purl.uniprot.org/citations/30716474 | http://purl.uniprot.org/core/author | "Duan X."xsd:string |
| http://purl.uniprot.org/citations/30716474 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30716474 | http://purl.uniprot.org/core/name | "Int J Biochem Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/30716474 | http://purl.uniprot.org/core/pages | "33-39"xsd:string |
| http://purl.uniprot.org/citations/30716474 | http://purl.uniprot.org/core/title | "Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia."xsd:string |
| http://purl.uniprot.org/citations/30716474 | http://purl.uniprot.org/core/volume | "109"xsd:string |
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