| http://purl.uniprot.org/citations/30717343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30717343 | http://www.w3.org/2000/01/rdf-schema#comment | "Columbianadin (CBN) is one of the main bioactive constituents isolated from the root of Angelica pubescens. Although the anti-inflammatory activity of CBN has been reported, the underpinning mechanism of this remains unclear. In this study, we investigated the anti-inflammatory effect of CBN on lipopolysaccharide (LPS)-stimulated THP-1 cells and explored the possible underlying molecular mechanisms. The results showed that CBN suppressed LPS-mediated inflammatory response mainly through the inactivation of the NOD1 and NF-κ B p65 signaling pathways. Knockdown of NOD1 reduced the degree to which inflammatory cytokines decreased following CBN treatment, whereas forced expression of NOD1 and CBN treatment reduced NF-κ B p65 activation and the secretion of inflammatory cytokines. Furthermore, CBN significantly reduced cellular apoptosis by inhibiting the NOD1 pathway. Collectively, our results indicate that CBN suppressed the LPS-mediated inflammatory response by inhibiting NOD1/NF-κ B activation. Further investigations are required to determine the mechanisms of action of CBN in the inhibition of NOD signaling: However, CBN may be employed as a therapeutic agent for multiple inflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.org/dc/terms/identifier | "doi:10.3390/molecules24030549"xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/author | "Gu Y."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/author | "Dong B."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/author | "Pan H."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/author | "Zheng R."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/author | "Zuo X."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/author | "Hsu A.C."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/name | "Molecules"xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/pages | "E549"xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/title | "Columbianadin Suppresses Lipopolysaccharide (LPS)-Induced Inflammation and Apoptosis through the NOD1 Pathway."xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/30717343 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30717343 |
| http://purl.uniprot.org/citations/30717343 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30717343 |
| http://purl.uniprot.org/uniprot/#_A0A087X0W8-mappedCitation-30717343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30717343 |
| http://purl.uniprot.org/uniprot/#_A0A024RA73-mappedCitation-30717343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30717343 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4W5-mappedCitation-30717343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30717343 |
| http://purl.uniprot.org/uniprot/#_B3KN80-mappedCitation-30717343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30717343 |