| http://purl.uniprot.org/citations/30717807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30717807 | http://www.w3.org/2000/01/rdf-schema#comment | "The current histopathological risk-stratification criteria in colorectal cancer (CRC) patients following a curative surgery remain inadequate. In this study, we undertook a systematic, genomewide, biomarker discovery approach to identify and validate key EMT-associated genes that may facilitate recurrence prediction in CRC. Genomewide RNA expression profiling results from two datasets (GSE17538; N = 173 and GSE41258; N = 307) were used for biomarker discovery. These results were independently validated in two, large, clinical cohorts (testing cohort; N = 201 and validation cohort; N = 468). We performed Gene Set Enrichment Analysis (GSEA) for understanding the function of the candidate markers, and evaluated their correlation with the mesenchymal CMS4 subtype. We identified integrin subunit beta like 1 (ITGBL1) as a promising candidate biomarker, and its high expression associated with poor overall survival (OS) in stage I-IV patients and relapse-free survival (RFS) in stage I-III patients. Subgroup validation in multiple independent patient cohorts confirmed these findings, and demonstrated that high ITGBL1 expression correlated with shorter RFS in stage II patients. We developed a RFS prediction model which robustly predicted RFS (the area under the receiver operating curve (AUROC): 0.74; hazard ratio (HR): 2.72) in CRC patients. ITGBL1 is a promising EMT-associated biomarker for recurrence prediction in CRC patients, which may contribute to improved risk-stratification in CRC."xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.org/dc/terms/identifier | "doi:10.1186/s12943-019-0945-y"xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/author | "Ishikawa T."xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/author | "Matsuyama T."xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/author | "Kawano T."xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/author | "Yamada Y."xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/author | "Takahashi N."xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/author | "Goel A."xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/author | "Uetake H."xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/author | "Yasuno M."xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/name | "Mol Cancer"xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/pages | "19"xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/title | "Transcriptomic expression profiling identifies ITGBL1, an epithelial to mesenchymal transition (EMT)-associated gene, is a promising recurrence prediction biomarker in colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/30717807 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30717807 |
| http://purl.uniprot.org/citations/30717807 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30717807 |
| http://purl.uniprot.org/uniprot/#_A0A087WY35-mappedCitation-30717807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30717807 |
| http://purl.uniprot.org/uniprot/#_B4DN32-mappedCitation-30717807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30717807 |
| http://purl.uniprot.org/uniprot/#_O14549-mappedCitation-30717807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30717807 |
| http://purl.uniprot.org/uniprot/#_O95965-mappedCitation-30717807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30717807 |
| http://purl.uniprot.org/uniprot/A0A087WY35 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30717807 |
| http://purl.uniprot.org/uniprot/O95965 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30717807 |
| http://purl.uniprot.org/uniprot/O14549 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30717807 |