| http://purl.uniprot.org/citations/30721152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30721152 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased airway vagal sensory C-fiber activity contributes to the symptoms of inflammatory airway diseases. The KCNQ/Kv7/M-channel is a well-known determinant of neuronal excitability, yet whether it regulates the activity of vagal bronchopulmonary C-fibers and airway reflex sensitivity remains unknown. Here we addressed this issue using single-cell RT-PCR, patch clamp technique, extracellular recording of single vagal nerve fibers innervating the mouse lungs, and telemetric recording of cough in free-moving mice. Single-cell mRNA analysis and biophysical properties of M-current (IM) suggest that KCNQ3/Kv7.3 is the major M-channel subunit in mouse nodose neurons. The M-channel opener retigabine negatively shifted the voltage-dependent activation of IM, leading to membrane hyperpolarization, increased rheobase, and suppression of both evoked and spontaneous action potential (AP) firing in nodose neurons in an M-channel inhibitor XE991-sensitive manner. Retigabine also markedly suppressed the α,β-methylene ATP-induced AP firing in nodose C-fiber terminals innervating the mouse lungs, and coughing evoked by irritant gases in awake mice. In conclusion, KCNQ/M-channels play a role in regulating the excitability of vagal airway C-fibers at both the cell soma and nerve terminals. Drugs that open M-channels in airway sensory afferents may relieve the sufferings associated with pulmonary inflammatory diseases such as chronic coughing."xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.124467"xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://purl.uniprot.org/core/author | "Sun H."xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://purl.uniprot.org/core/author | "Lee L.Y."xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://purl.uniprot.org/core/author | "Lin A.H."xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://purl.uniprot.org/core/author | "Meeker S."xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://purl.uniprot.org/core/author | "Ru F."xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://purl.uniprot.org/core/author | "Undem B.J."xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://purl.uniprot.org/core/author | "Patil M.J."xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30721152 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://purl.uniprot.org/core/pages | "124467"xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://purl.uniprot.org/core/title | "KCNQ/M-channels regulate mouse vagal bronchopulmonary C-fiber excitability and cough sensitivity."xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/30721152 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30721152 |
| http://purl.uniprot.org/citations/30721152 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30721152 |
| http://purl.uniprot.org/uniprot/#_A0A087WNY7-mappedCitation-30721152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30721152 |
| http://purl.uniprot.org/uniprot/#_P97414-mappedCitation-30721152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30721152 |
| http://purl.uniprot.org/uniprot/#_Q3UWF6-mappedCitation-30721152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30721152 |
| http://purl.uniprot.org/uniprot/#_Q4L139-mappedCitation-30721152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30721152 |
| http://purl.uniprot.org/uniprot/#_Q99NF6-mappedCitation-30721152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30721152 |
| http://purl.uniprot.org/uniprot/#_Q8CJG2-mappedCitation-30721152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30721152 |
| http://purl.uniprot.org/uniprot/P97414 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30721152 |
| http://purl.uniprot.org/uniprot/Q3UWF6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30721152 |