| http://purl.uniprot.org/citations/30737382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30737382 | http://www.w3.org/2000/01/rdf-schema#comment | "Retrograde BMP trans-synaptic signaling is essential for synaptic development. Despite the importance of endocytosis-regulated BMP receptor (BMPR) control of this developmental signaling, the mechanism remains unknown. Here, we provide evidence that Abelson interactor (Abi), a substrate for Abl kinase and component of the SCAR/WAVE complex, links Abl and Rac1 GTPase signaling to BMPR macropinocytosis to restrain BMP-mediated synaptic development. We find that Abi acts downstream of Abl and Rac1, and that BMP ligand Glass bottom boat (Gbb) induces macropinocytosis dependent on Rac1/SCAR signaling, Abl-mediated Abi phosphorylation, and BMPR activation. Macropinocytosis acts as the major internalization route for BMPRs at the synapse in a process driven by Gbb activation and resulting in receptor degradation. Key regulators of macropinocytosis (Rabankyrin and CtBP) control BMPR trafficking to limit BMP trans-synaptic signaling. We conclude that BMP-induced macropinocytosis acts as a BMPR homeostatic mechanism to regulate BMP-mediated synaptic development."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-08533-2"xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/author | "Lee M."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/author | "Kim N."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/author | "Lee M.J."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/author | "Nahm M."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/author | "Cho E."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/author | "Broadie K."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/author | "Kopke D."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/pages | "684"xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/title | "BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis."xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/30737382 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30737382 |
| http://purl.uniprot.org/citations/30737382 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30737382 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFN9-mappedCitation-30737382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30737382 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFT4-mappedCitation-30737382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30737382 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFX5-mappedCitation-30737382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30737382 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGZ7-mappedCitation-30737382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30737382 |