| http://purl.uniprot.org/citations/30738250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30738250 | http://www.w3.org/2000/01/rdf-schema#comment | "The maintenance of intestinal tissue homeostasis is vital for the resistance against inflammatory bowel diseases (IBDs). Necroptosis is identified as an alternative mode of regulated cell death, which plays a pivotal role in tissue homeostasis. Thus, the roles of RIP3-mediated necroptosis in intestinal inflammation have been extensively studied. However, the biological implications of the mixed lineage kinase-like protein (MLKL), a molecule downstream of RIP3 in gut remain unclear. In this study, the role of MLKL in DSS-induced colitis was examined, and the contribution of gut microbiota was also determined. Compared with non-littermate WT mice, the survival rate, clinical score, intestinal damage and intestinal mucosal barrier integrity of non-littermate MLKL-deficient mice are significantly improved. MLKL deficiency prevents inflammatory cytokines production and MAPK signaling activation. Hence, MLKL deficiency inhibits DSS-induced colitis. Moreover, we proved that DSS susceptibility difference between two genotypes is not driven by intestinal microbiota based on the co-housing of two non-littermate genotypes and qPCR detection of fecal dominant bacterial taxa."xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2019.01.018"xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://purl.uniprot.org/core/author | "Hu G.Q."xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://purl.uniprot.org/core/author | "Yang Y.J."xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://purl.uniprot.org/core/author | "Qin D."xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://purl.uniprot.org/core/author | "Qin X.X."xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://purl.uniprot.org/core/author | "Du C.T."xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30738250 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://purl.uniprot.org/core/pages | "132-141"xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://purl.uniprot.org/core/title | "MLKL deficiency inhibits DSS-induced colitis independent of intestinal microbiota."xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/30738250 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30738250 |
| http://purl.uniprot.org/citations/30738250 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30738250 |
| http://purl.uniprot.org/uniprot/#_D3YV42-mappedCitation-30738250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30738250 |
| http://purl.uniprot.org/uniprot/#_Q9D2Y4-mappedCitation-30738250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30738250 |
| http://purl.uniprot.org/uniprot/D3YV42 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30738250 |
| http://purl.uniprot.org/uniprot/Q9D2Y4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30738250 |