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http://purl.uniprot.org/citations/30755060http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30755060http://www.w3.org/2000/01/rdf-schema#comment"

Introduction:

Apelin plays an important part in regulating blood pressure, metabolism, and the development of cancer. Recent studies have investigated the association of apelin polymorphisms and hypertension risk, but no meta-analysis has been conducted.

Materials and methods:

Five studies were included in this meta-analysis in total. The pooled odds ratio and its corresponding 95% confidence interval were calculated by the random-effect model.

Results:

The overall pooled odds ratio of the distribution of rs3761581 G allelic frequency was 0.90 (95% confidence interval: 0.82-1.00). In female participants, the pooled odds ratio of the frequency of G allele was 1.01 (95% confidence interval: 0.89-1.14). For males, the pooled odds ratio of the frequency of G allele was 0.69 (95% confidence interval: 0.46-1.03). As for rs56204867, the overall pooled odds ratio of the frequency of G allele was 1.09 (95% confidence interval: 0.86-1.37). In females, the pooled odds ratio of the frequencies of the G allele was 1.05 (95% confidence interval: 0.86-1.29). In male participants, the frequency of G allele did not show significant correlation with hypertension (pooled odds ratio=1.21 95% confidence interval: 0.81-1.79).

Conclusion:

This meta-analysis revealed that there was no correlation between apelin polymorphisms, rs3761581 and rs56204867, and the prevalence of hypertension."xsd:string
http://purl.uniprot.org/citations/30755060http://purl.org/dc/terms/identifier"doi:10.1177/1470320319827204"xsd:string
http://purl.uniprot.org/citations/30755060http://purl.uniprot.org/core/author"Ding J."xsd:string
http://purl.uniprot.org/citations/30755060http://purl.uniprot.org/core/author"Liu C."xsd:string
http://purl.uniprot.org/citations/30755060http://purl.uniprot.org/core/author"Wang T."xsd:string
http://purl.uniprot.org/citations/30755060http://purl.uniprot.org/core/author"Jia L."xsd:string
http://purl.uniprot.org/citations/30755060http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/30755060http://purl.uniprot.org/core/name"J Renin Angiotensin Aldosterone Syst"xsd:string
http://purl.uniprot.org/citations/30755060http://purl.uniprot.org/core/pages"1470320319827204"xsd:string
http://purl.uniprot.org/citations/30755060http://purl.uniprot.org/core/title"The association between apelin polymorphisms and hypertension in China: A meta-analysis."xsd:string
http://purl.uniprot.org/citations/30755060http://purl.uniprot.org/core/volume"20"xsd:string
http://purl.uniprot.org/citations/30755060http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/30755060
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