| http://purl.uniprot.org/citations/30773781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30773781 | http://www.w3.org/2000/01/rdf-schema#comment | "PDZ domain-containing proteins (PDZ proteins) act as scaffolds for protein-protein interactions and are crucial for a variety of signal transduction processes. However, the role of PDZ proteins in organismal lifespan and aging remains poorly understood. Here, we demonstrate that KIN-4, a PDZ domain-containing microtubule-associated serine-threonine (MAST) protein kinase, is a key longevity factor acting through binding PTEN phosphatase in Caenorhabditis elegans. Through a targeted genetic screen for PDZ proteins, we find that kin-4 is required for the long lifespan of daf-2/insulin/IGF-1 receptor mutants. We then show that neurons are crucial tissues for the longevity-promoting role of kin-4. We find that the PDZ domain of KIN-4 binds PTEN, a key factor for the longevity of daf-2 mutants. Moreover, the interaction between KIN-4 and PTEN is essential for the extended lifespan of daf-2 mutants. As many aspects of lifespan regulation in C. elegans are evolutionarily conserved, MAST family kinases may regulate aging and/or age-related diseases in mammals through their interaction with PTEN."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.org/dc/terms/identifier | "doi:10.1111/acel.12906"xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Park S.K."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Mori I."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Nakano S."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Choi E.S."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Hwang W."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Yoo J.Y."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Nam H.J."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Seo K."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Yang J.S."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Ryu Y."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Lee S.V."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Nguyen N.T.H."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Son H.G."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Suh B.K."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "An S.W.A."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Kim E.J.E."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/author | "Man Ha C."xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/name | "Aging Cell"xsd:string |
| http://purl.uniprot.org/citations/30773781 | http://purl.uniprot.org/core/pages | "e12906"xsd:string |