| http://purl.uniprot.org/citations/30775439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30775439 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid-inducible gene I (RIG-I), a pivotal cytosolic sensor, recognizes viral RNAs to initiate antiviral innate immunity. However, posttranslational regulation of RIG-I signaling is not well understood. We report here that nuclear Dbf2-related kinase 2 (NDR2) functions as a crucial positive regulator of the RIG-I-mediated antiviral immune response. Overexpression of NDR2 or its kinase-inactive mutants potentiates RNA virus-induced production of type I interferons and proinflammatory cytokines and dampens viral replication. NDR2 conditional knockout mice (Lysm+NDR2f/f) show an impaired antiviral immune response. Mechanistically, NDR2 directly associates with RIG-I and TRIM25, thus facilitating the RIG-I/TRIM25 complex and enhancing the TRIM25-mediated K63-linked polyubiquitination of RIG-I, which is required for the RIG-I-mediated antiviral immune response. Furthermore, NDR2 expression is notably down-regulated in peripheral blood from respiratory syncytial virus-infected patients and in virus-infected macrophages. Collectively, these findings provide insights into the function of NDR2 in antiviral immunity and its related clinical significance."xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.aav0163"xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/author | "Gu M."xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/author | "Pan Y."xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/author | "Wang X.'"xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/pages | "eaav0163"xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/title | "NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages."xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/30775439 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30775439 |
| http://purl.uniprot.org/citations/30775439 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30775439 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BS20-mappedCitation-30775439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30775439 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPL1-mappedCitation-30775439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30775439 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPW0-mappedCitation-30775439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30775439 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQM5-mappedCitation-30775439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30775439 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQR5-mappedCitation-30775439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30775439 |
| http://purl.uniprot.org/uniprot/#_B7Z8G6-mappedCitation-30775439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30775439 |