| http://purl.uniprot.org/citations/30776374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30776374 | http://www.w3.org/2000/01/rdf-schema#comment | "GCN5L1 regulates mitochondrial protein acetylation, cellular bioenergetics, reactive oxygen species (ROS) generation, and organelle positioning in a number of diverse cell types. However, the functional role of GCN5L1 in the heart is currently unknown. As many of the factors regulated by GCN5L1 play a major role in ischemia-reperfusion (I/R) injury, we sought to determine if GCN5L1 is an important nexus in the response to cardiac ischemic stress. Deletion of GCN5L1 in cardiomyocytes resulted in impaired myocardial post-ischemic function and increased infarct development in isolated work-performing hearts. GCN5L1 knockout hearts displayed hallmarks of ROS damage, and scavenging of ROS restored cardiac function and reduced infarct volume in vivo. GCN5L1 knockdown in cardiac-derived AC16 cells was associated with reduced activation of the pro-survival MAP kinase ERK1/2, which was also reversed by ROS scavenging, leading to restored cell viability. We therefore conclude that GCN5L1 activity provides an important protection against I/R induced, ROS-mediated damage in the ischemic heart."xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yjmcc.2019.02.009"xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/author | "Scott I."xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/author | "Sack M.N."xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/author | "Corey C."xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/author | "Shiva S."xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/author | "McTiernan C.F."xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/author | "Traba J."xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/author | "Thapa D."xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/author | "Stoner M.W."xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/author | "Manning J.R."xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/name | "J Mol Cell Cardiol"xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/pages | "69-78"xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/title | "Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury."xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/30776374 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30776374 |
| http://purl.uniprot.org/citations/30776374 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30776374 |
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| http://purl.uniprot.org/uniprot/#_P78537-mappedCitation-30776374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30776374 |
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| http://purl.uniprot.org/uniprot/#_O55102-mappedCitation-30776374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30776374 |