| http://purl.uniprot.org/citations/30777853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30777853 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in tumor-bearing mice the macrophage colony-stimulating factor elevates the myeloid cell levels of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD salvage pathway, which acts as negative regulator of the CXCR4 retention axis of hematopoietic cells in the bone marrow. NAMPT inhibits CXCR4 through a NAD/Sirtuin 1-mediated inactivation of HIF1α-driven CXCR4 gene transcription, leading to mobilization of immature myeloid-derived suppressor cells (MDSC) and enhancing their production of suppressive nitric oxide. Pharmacologic inhibition or myeloid-specific ablation of NAMPT prevented MDSC mobilization, reactivated specific antitumor immunity, and enhanced the antitumor activity of immune checkpoint inhibitors. Our findings identify NAMPT as a metabolic gate of MDSC precursor function, providing new opportunities to reverse tumor immunosuppression and to restore clinical efficacy of immunotherapy in patients with cancer. SIGNIFICANCE: These findings identify NAMPT as a metabolic gate of MDSC precursor function, providing new opportunities to reverse tumor immunosuppression and to restore clinical efficacy of immunotherapy in cancer patients."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-18-1544"xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Trovato R."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Storto M."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Tripodo C."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Morlacchi S."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Genazzani A.A."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Mazzone M."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Colombo M.P."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Galli U."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Sica A."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Sangaletti S."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Bronte V."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Rimassa L."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Ugel S."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Portararo P."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Consonni F.M."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Grolla A.A."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Travelli C."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Pressiani T."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/author | "Tron G.C."xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/30777853 | http://purl.uniprot.org/core/pages | "1938-1951"xsd:string |