| http://purl.uniprot.org/citations/30779114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30779114 | http://www.w3.org/2000/01/rdf-schema#comment | "Baseline eosinophils reside in the gastrointestinal tract; however, in several allergic disorders, excessive eosinophils accumulate in the blood as well in the tissues. Recently, we showed in vitro that interleukin (IL)-18 matures and transforms IL-5-generated eosinophils into the pathogenic eosinophils that are detected in human allergic diseases. To examine the role of local induction of IL-18 in promoting eosinophil-associated intestinal disorders, we generated enterocyte IL-18-overexpressing mice using the rat intestinal fatty acid-binding promoter (Fabpi) and analysed tissue IL-18 overexpression and eosinophilia by performing real-time polymerase chain reaction, Enzyme-Linked Immunosorbent Assay and anti-major basic protein immunostaining. Herein we show that Fabpi-IL-18 mice display highly induced IL-18 mRNA and protein in the jejunum. IL-18 overexpression in enterocytes promotes marked increases of eosinophils in the blood and jejunum. Our analysis shows IL-18 overexpression in the jejunum induces a specific population of CD101+ CD274+ tissue eosinophils. Additionally, we observed comparable tissue eosinophilia in IL-13-deficient-Fabpi-IL-18 mice, and reduced numbers of tissue eosinophils in eotaxin-deficient-Fabpi-IL-18 and IL-5-deficient-Fabpi-IL-18 mice compared with Fabpi-IL-18 transgenic mice. Notably, jejunum eosinophilia in IL-5-deficient-Fabpi-IL-18 mice is significantly induced compared with wild-type mice, which indicates the direct role of induced IL-18 in the tissue accumulation of eosinophils and mast cells. Furthermore, we also found that overexpression of IL-18 in the intestine promotes eosinophil-associated peanut-induced allergic responses in mice. Taken together, we provide direct in vivo evidence that induced expression of IL-18 in the enterocytes promotes eotaxin-1, IL-5 and IL-13 independent intestinal eosinophilia, which signifies the clinical relevance of induced IL-18 in eosinophil-associated gastrointestinal disorders (EGIDs) to food allergens."xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://purl.org/dc/terms/identifier | "doi:10.1111/imm.13051"xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://purl.uniprot.org/core/author | "Verma A.K."xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://purl.uniprot.org/core/author | "Shukla A."xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://purl.uniprot.org/core/author | "Mishra A."xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://purl.uniprot.org/core/author | "Manohar M."xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://purl.uniprot.org/core/author | "Kandikattu H.K."xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://purl.uniprot.org/core/author | "Upparahalli Venkateshaiah S."xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30779114 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://purl.uniprot.org/core/pages | "110-121"xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://purl.uniprot.org/core/title | "Intestinal overexpression of IL-18 promotes eosinophils-mediated allergic disorders."xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://purl.uniprot.org/core/volume | "157"xsd:string |
| http://purl.uniprot.org/citations/30779114 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30779114 |
| http://purl.uniprot.org/citations/30779114 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30779114 |
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