| http://purl.uniprot.org/citations/30783137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30783137 | http://www.w3.org/2000/01/rdf-schema#comment | "Changes in cell function occur by specific patterns of intracellular Ca2+, activating Ca2+-sensitive proteins. The anoctamin (TMEM16) protein family has Ca2+-dependent ion channel activity, which provides transmembrane ion transport, and/or Ca2+-dependent phosphatidyl-scramblase activity. Using amino acid sequence analysis combined with measurements of ion channel function, we clarified the so far unknown Ano4 function as Ca2+-dependent, non-selective monovalent cation channel; heterologous Ano4 expression in HEK293 cells elicits Ca2+ activated conductance with weak selectivity of K+ > Na+ > Li+. Endogenously expressed Ca2+-dependent cation channels in the retinal pigment epithelium were identified as Ano4 by KO mouse-derived primary RPE cells and siRNA against Ano4. Exchanging a negatively charged amino acid in the putative pore region (AA702-855) into a positive one (E775K) turns Ano4-elicited currents into Cl- currents evidencing its importance for ion selectivity. The molecular identification of Ano4 as a Ca2+-activated cation channel advances the understanding of its role in Ca2+ signaling."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-37287-y"xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Cordes M."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Klussmann E."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Fels G."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Milenkovic V.M."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Strauss O."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Rauh R."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Haeckel A."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Schellenberger E."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Kociok N."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Mataruga A."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Zuhlke K."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Reichhart N."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Roubeix C."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Crespo-Garcia S."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Fockler R."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Keckeis S."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Alfaar A.S."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/author | "Schoberl S."xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/pages | "2257"xsd:string |
| http://purl.uniprot.org/citations/30783137 | http://purl.uniprot.org/core/title | "Anoctamin-4 is a bona fide Ca2+-dependent non-selective cation channel."xsd:string |