| http://purl.uniprot.org/citations/30791982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30791982 | http://www.w3.org/2000/01/rdf-schema#comment | "Irritant contact dermatitis (ICD) is one of the most common inflammatory skin diseases caused by exposure to chemical irritants. Since chemical irritants primarily damage keratinocytes, these cells play a pivotal role in ICD. One of the phosphoinositide-metabolizing enzymes, phospholipase C (PLC) δ1, is abundantly expressed in keratinocytes. However, the role of PLCδ1 in ICD remains to be clarified. Here, we found that croton oil (CrO)-induced ear swelling, a feature of ICD, was attenuated in keratinocyte-specific PLCδ1 knockout mice (PLCδ1 cKO mice). Dendritic epidermal T cells (DETCs), which have a protective role against ICD, were activated in the epidermis of the PLCδ1 cKO mice. In addition, the skin of CrO-treated PLCδ1 cKO mice showed increased infiltration of Gr1+CD11b+ myeloid cells. Of note, elimination of Gr1+CD11b+ myeloid cells restored CrO-induced ear swelling in PLCδ1 cKO mice to a similar level as that in control mice. Taken together, our results strongly suggest that epidermal loss of PLCδ1 protects mice from ICD through induction of Gr1+CD11b+ myeloid cells and activation of DETCs."xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2019.02.046"xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/author | "Nakajima A."xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/author | "Ogura T."xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/author | "Fukami K."xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/author | "Fukuyama T."xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/author | "Shiratori K."xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/author | "Kanemaru K."xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/author | "Sugizaki Y."xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/pages | "330-335"xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/title | "Epidermal loss of phospholipase Cdelta1 attenuates irritant contact dermatitis."xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://purl.uniprot.org/core/volume | "511"xsd:string |
| http://purl.uniprot.org/citations/30791982 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30791982 |
| http://purl.uniprot.org/citations/30791982 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30791982 |
| http://purl.uniprot.org/uniprot/#_A0A087WQB4-mappedCitation-30791982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30791982 |
| http://purl.uniprot.org/uniprot/#_A0A384MR47-mappedCitation-30791982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30791982 |
| http://purl.uniprot.org/uniprot/#_A8K8F9-mappedCitation-30791982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30791982 |
| http://purl.uniprot.org/uniprot/#_B3KXR5-mappedCitation-30791982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30791982 |
| http://purl.uniprot.org/uniprot/#_Q62386-mappedCitation-30791982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30791982 |
| http://purl.uniprot.org/uniprot/#_Q7TNI7-mappedCitation-30791982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30791982 |