| http://purl.uniprot.org/citations/30792173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30792173 | http://www.w3.org/2000/01/rdf-schema#comment | "The 26S proteasome is the ATP-dependent protease responsible for regulating the proteome of eukaryotic cells through degradation of mainly ubiquitin-tagged substrates. In order to understand how proteasome responds to ubiquitin signal, we resolved an ensemble of cryo-EM structures of proteasome in the presence of K48-Ub4, with three of them resolved at near-atomic resolution. We identified a conformation with stabilized ubiquitin receptors and a previously unreported orientation of the lid, assigned as a Ub-accepted state C1-b. We determined another structure C3-b with localized K48-Ub4 to the toroid region of Rpn1, assigned as a substrate-processing state. Our structures indicate that tetraUb induced conformational changes in proteasome could initiate substrate degradation. We also propose a CP gate-opening mechanism involving the propagation of the motion of the lid to the gate through the Rpn6-α2 interaction. Our results enabled us to put forward a model of a functional cycle for proteasomes induced by tetraUb and nucleotide."xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2019.01.018"xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/author | "Fu Z."xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/author | "Cong Y."xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/author | "Huang M."xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/author | "Ding Z."xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/author | "Glickman M.H."xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/author | "Wong C.C.L."xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/author | "Sahu I."xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/pages | "1150-1161.e6"xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/title | "Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations."xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/30792173 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30792173 |
| http://purl.uniprot.org/citations/30792173 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30792173 |
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| http://purl.uniprot.org/uniprot/#_P38624-mappedCitation-30792173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30792173 |