| http://purl.uniprot.org/citations/30794774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30794774 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased levels of intestinal bile acids (BAs) are a risk factor for colorectal cancer (CRC). Here, we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT signaling (APC mutation) alters BA profiles to drive malignant transformations in Lgr5-expressing (Lgr5+) cancer stem cells and promote an adenoma-to-adenocarcinoma progression. Mechanistically, we show that BAs that antagonize intestinal farnesoid X receptor (FXR) function, including tauro-β-muricholic acid (T-βMCA) and deoxycholic acid (DCA), induce proliferation and DNA damage in Lgr5+ cells. Conversely, selective activation of intestinal FXR can restrict abnormal Lgr5+ cell growth and curtail CRC progression. This unexpected role for FXR in coordinating intestinal self-renewal with BA levels implicates FXR as a potential therapeutic target for CRC."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2019.01.036"xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Downes M."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "He M."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Zhu Q."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Leblanc M."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Knight R."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Fu T."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Fang S."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Yu R.T."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Schnabl B."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Atkins A.R."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Liddle C."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Coulter S."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Yoshihara E."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Oh T.G."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Gasser E."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Waizenegger W."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/author | "Cayabyab F."xsd:string |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30794774 | http://purl.uniprot.org/core/name | "Cell"xsd:string |