| http://purl.uniprot.org/citations/30796047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30796047 | http://www.w3.org/2000/01/rdf-schema#comment | "Self-renewal of intestinal stem cells is controlled by Wingless/Wnt-β catenin signaling in both Drosophila and mammals. As Axin is a rate-limiting factor in Wingless signaling, its regulation is essential. Iduna is an evolutionarily conserved ubiquitin E3 ligase that has been identified as a crucial regulator for degradation of ADP-ribosylated Axin and, thus, of Wnt/β-catenin signaling. However, its physiological significance remains to be demonstrated. Here, we generated loss-of-function mutants of Iduna to investigate its physiological role in Drosophila Genetic depletion of Iduna causes the accumulation of both Tankyrase and Axin. Increase of Axin protein in enterocytes non-autonomously enhanced stem cell divisions in the Drosophila midgut. Enterocytes secreted Unpaired proteins and thereby stimulated the activity of the JAK-STAT pathway in intestinal stem cells. A decrease in Axin gene expression suppressed the over-proliferation of stem cells and restored their numbers to normal levels in Iduna mutants. These findings suggest that Iduna-mediated regulation of Axin proteolysis is essential for tissue homeostasis in the Drosophila midgut."xsd:string |
| http://purl.uniprot.org/citations/30796047 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.169284"xsd:string |
| http://purl.uniprot.org/citations/30796047 | http://purl.uniprot.org/core/author | "Steller H."xsd:string |
| http://purl.uniprot.org/citations/30796047 | http://purl.uniprot.org/core/author | "Gultekin Y."xsd:string |
| http://purl.uniprot.org/citations/30796047 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30796047 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/30796047 | http://purl.uniprot.org/core/pages | "dev169284"xsd:string |
| http://purl.uniprot.org/citations/30796047 | http://purl.uniprot.org/core/title | "Axin proteolysis by Iduna is required for the regulation of stem cell proliferation and intestinal homeostasis in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/30796047 | http://purl.uniprot.org/core/volume | "146"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KHS7-mappedCitation-30796047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30796047 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHW0-mappedCitation-30796047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30796047 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI19-mappedCitation-30796047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30796047 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KGI7-mappedCitation-30796047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30796047 |
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| http://purl.uniprot.org/uniprot/#_B7Z0S0-mappedCitation-30796047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30796047 |
| http://purl.uniprot.org/uniprot/#_B7Z078-mappedCitation-30796047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30796047 |
| http://purl.uniprot.org/uniprot/#_B7Z083-mappedCitation-30796047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30796047 |
| http://purl.uniprot.org/uniprot/#_E1JJ18-mappedCitation-30796047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30796047 |