| http://purl.uniprot.org/citations/30801823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30801823 | http://www.w3.org/2000/01/rdf-schema#comment | "Nicotinamide adenine dinucleotide (NAD+ ) is a central signaling molecule and enzyme cofactor that is involved in a variety of fundamental biological processes. NAD+ levels decline with age, neurodegenerative conditions, acute brain injury, and in obesity or diabetes. Loss of NAD+ results in impaired mitochondrial and cellular functions. Administration of NAD+ precursor, nicotinamide mononucleotide (NMN), has shown to improve mitochondrial bioenergetics, reverse age-associated physiological decline, and inhibit postischemic NAD+ degradation and cellular death. In this study, we identified a novel link between NAD+ metabolism and mitochondrial dynamics. A single dose (62.5 mg/kg) of NMN, administered to male mice, increases hippocampal mitochondria NAD+ pools for up to 24 hr posttreatment and drives a sirtuin 3 (SIRT3)-mediated global decrease in mitochondrial protein acetylation. This results in a reduction of hippocampal reactive oxygen species levels via SIRT3-driven deacetylation of mitochondrial manganese superoxide dismutase. Consequently, mitochondria in neurons become less fragmented due to lower interaction of phosphorylated fission protein, dynamin-related protein 1 (pDrp1 [S616]), with mitochondria. In conclusion, manipulation of mitochondrial NAD+ levels by NMN results in metabolic changes that protect mitochondria against reactive oxygen species and excessive fragmentation, offering therapeutic approaches for pathophysiologic stress conditions."xsd:string |
| http://purl.uniprot.org/citations/30801823 | http://purl.org/dc/terms/identifier | "doi:10.1002/jnr.24397"xsd:string |
| http://purl.uniprot.org/citations/30801823 | http://purl.uniprot.org/core/author | "Long A."xsd:string |
| http://purl.uniprot.org/citations/30801823 | http://purl.uniprot.org/core/author | "Klimova N."xsd:string |
| http://purl.uniprot.org/citations/30801823 | http://purl.uniprot.org/core/author | "Kristian T."xsd:string |
| http://purl.uniprot.org/citations/30801823 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30801823 | http://purl.uniprot.org/core/name | "J Neurosci Res"xsd:string |
| http://purl.uniprot.org/citations/30801823 | http://purl.uniprot.org/core/pages | "975-990"xsd:string |
| http://purl.uniprot.org/citations/30801823 | http://purl.uniprot.org/core/title | "Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice."xsd:string |
| http://purl.uniprot.org/citations/30801823 | http://purl.uniprot.org/core/volume | "97"xsd:string |
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