| http://purl.uniprot.org/citations/30806032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30806032 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundAlthough cigarette smoking is considered one of the key risk factors for lung cancer, 15% of male patients and 53% of female patients with lung cancer are non-smokers. Metabolic changes are critical features of cancer. Therapeutic target identification from a metabolic perspective in non-small cell lung cancer (NSCLC) tissue of female non-smokers has long been ignored.ResultsBased on microarray data retrieved from Affymetrix expression arrays E-GEOD-19804, we found that the downregulated genes in non-smoking female NSCLC patients tended to participate in protein/amino acid and lipid metabolism, while upregulated genes were more involved in protein/amino acid and carbohydrate metabolism. Combining nutrient metabolic co-expression, protein-protein interaction network construction and overall survival assessment, we identified NR4A1 and TIE1 as potential therapeutic targets for NSCLC in female non-smokers. To accelerate the drug development for non-smoking female NSCLC patients, we identified nilotinib as a potential agonist targeting NR4A1 encoded protein by molecular docking and molecular dynamic stimulation. We also show that nilotinib inhibited proliferation and induced senescence of cells in non-smoking female NSCLC patients in vitro.ConclusionsThese results not only uncover nutrient metabolic characteristics in non-smoking female NSCLC patients, but also provide a new paradigm for identifying new targets and drugs for novel therapy for such patients."xsd:string |
| http://purl.uniprot.org/citations/30806032 | http://purl.org/dc/terms/identifier | "doi:10.1111/1759-7714.12989"xsd:string |
| http://purl.uniprot.org/citations/30806032 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/30806032 | http://purl.uniprot.org/core/author | "Long X."xsd:string |
| http://purl.uniprot.org/citations/30806032 | http://purl.uniprot.org/core/author | "Sun R."xsd:string |
| http://purl.uniprot.org/citations/30806032 | http://purl.uniprot.org/core/author | "Yuan Y."xsd:string |
| http://purl.uniprot.org/citations/30806032 | http://purl.uniprot.org/core/author | "Wu M.M."xsd:string |
| http://purl.uniprot.org/citations/30806032 | http://purl.uniprot.org/core/author | "Bao M.Y."xsd:string |
| http://purl.uniprot.org/citations/30806032 | http://purl.uniprot.org/core/author | "Bao J.K."xsd:string |
| http://purl.uniprot.org/citations/30806032 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30806032 | http://purl.uniprot.org/core/name | "Thorac Cancer"xsd:string |
| http://purl.uniprot.org/citations/30806032 | http://purl.uniprot.org/core/pages | "715-727"xsd:string |
| http://purl.uniprot.org/citations/30806032 | http://purl.uniprot.org/core/title | "Metabolic gene NR4A1 as a potential therapeutic target for non-smoking female non-small cell lung cancer patients."xsd:string |
| http://purl.uniprot.org/citations/30806032 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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