| http://purl.uniprot.org/citations/30808650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30808650 | http://www.w3.org/2000/01/rdf-schema#comment | "FUS (fused in sarcoma) plays a key role in several steps of RNA metabolism, and dominant mutations in this protein are associated with neurodegenerative diseases. Here, we show that FUS is a component of the cellular response to topoisomerase I (TOP1)-induced DNA breakage; relocalising to the nucleolus in response to RNA polymerase II (Pol II) stalling at sites of TOP1-induced DNA breaks. This relocalisation is rapid and dynamic, reversing following the removal of TOP1-induced breaks and coinciding with the recovery of global transcription. Importantly, FUS relocalisation following TOP1-induced DNA breakage is associated with increased FUS binding at sites of RNA polymerase I transcription in ribosomal DNA and reduced FUS binding at sites of RNA Pol II transcription, suggesting that FUS relocates from sites of stalled RNA Pol II either to regulate pre-mRNA processing during transcriptional stress or to modulate ribosomal RNA biogenesis. Importantly, FUS-mutant patient fibroblasts are hypersensitive to TOP1-induced DNA breakage, highlighting the possible relevance of these findings to neurodegeneration."xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.org/dc/terms/identifier | "doi:10.26508/lsa.201800222"xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/author | "Van Damme P."xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/author | "Caldecott K.W."xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/author | "Naumann M."xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/author | "Hermann A."xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/author | "Martinez-Macias M.I."xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/author | "Hafezparast M."xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/author | "Green R.L."xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/author | "Gomez-Herreros F."xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/author | "Moore D.A."xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/name | "Life Sci Alliance"xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/pages | "e201800222"xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/title | "FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress."xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/30808650 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30808650 |
| http://purl.uniprot.org/citations/30808650 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30808650 |
| http://purl.uniprot.org/uniprot/#_P56959-mappedCitation-30808650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30808650 |
| http://purl.uniprot.org/uniprot/#_Q3USY4-mappedCitation-30808650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30808650 |
| http://purl.uniprot.org/uniprot/#_Q564D0-mappedCitation-30808650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30808650 |
| http://purl.uniprot.org/uniprot/#_Q3UK30-mappedCitation-30808650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30808650 |
| http://purl.uniprot.org/uniprot/#_Q8CFQ9-mappedCitation-30808650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30808650 |
| http://purl.uniprot.org/uniprot/#_Q91VQ2-mappedCitation-30808650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30808650 |