| http://purl.uniprot.org/citations/30808706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30808706 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitotic spindle orientation must be tightly regulated during development and adult tissue homeostasis. It determines cell-fate specification and tissue architecture during asymmetric and symmetric cell division, respectively. Here, we uncover a novel role for Ephrin-Eph intercellular signaling in controlling mitotic spindle alignment in Drosophila optic lobe neuroepithelial cells through aPKC activity-dependent myosin II regulation. We show that conserved core components of the mitotic spindle orientation machinery, including Discs Large1, Mud/NuMA, and Canoe/Afadin, mislocalize in dividing Eph mutant neuroepithelial cells and produce spindle alignment defects in these cells when they are down-regulated. In addition, the loss of Eph leads to a Rho signaling-dependent activation of the PI3K-Akt1 pathway, enhancing cell proliferation within this neuroepithelium. Hence, Eph signaling is a novel extrinsic mechanism that regulates both spindle orientation and cell proliferation in the Drosophila optic lobe neuroepithelium. Similar mechanisms could operate in other Drosophila and vertebrate epithelia."xsd:string |
| http://purl.uniprot.org/citations/30808706 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201807157"xsd:string |
| http://purl.uniprot.org/citations/30808706 | http://purl.uniprot.org/core/author | "Franco M."xsd:string |
| http://purl.uniprot.org/citations/30808706 | http://purl.uniprot.org/core/author | "Carmena A."xsd:string |
| http://purl.uniprot.org/citations/30808706 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30808706 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/30808706 | http://purl.uniprot.org/core/pages | "1200-1217"xsd:string |
| http://purl.uniprot.org/citations/30808706 | http://purl.uniprot.org/core/title | "Eph signaling controls mitotic spindle orientation and cell proliferation in neuroepithelial cells."xsd:string |
| http://purl.uniprot.org/citations/30808706 | http://purl.uniprot.org/core/volume | "218"xsd:string |
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