| http://purl.uniprot.org/citations/30808749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30808749 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytochrome c oxidase (CcO) reduces dioxygen to water and harnesses the chemical energy to drive proton translocation across the inner mitochondrial membrane by an unresolved mechanism. By using time-resolved serial femtosecond crystallography, we identified a key oxygen intermediate of bovine CcO. It is assigned to the PR-intermediate, which is characterized by specific redox states of the metal centers and a distinct protein conformation. The heme a3 iron atom is in a ferryl (Fe4+ = O2-) configuration, and heme a and CuB are oxidized while CuA is reduced. A Helix-X segment is poised in an open conformational state; the heme a farnesyl sidechain is H-bonded to S382, and loop-I-II adopts a distinct structure. These data offer insights into the mechanism by which the oxygen chemistry is coupled to unidirectional proton translocation."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1814526116"xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Fromme P."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Fromme R."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Boutet S."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Nelson G."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Zatsepin N.A."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Yeh S.R."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Sierra R.G."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Batyuk A."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Ros A."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Lisova S."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Ishigami I."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Lewis-Ballester A."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Rousseau D.L."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Spence J.C.H."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Grant T.D."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Brehm G."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Echelmeier A."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Coe J.D."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/author | "Dobson Z.F."xsd:string |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30808749 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |